millions treated for hypothyroidism at risk for lung cancer

An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). PLoSone 2011, 11:e27547. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called subclinical hypothyroidism only detected via blood work. You are using an out of date browser. millions treated for hypothyroidism at risk for lung cancer The authors expanded on their findings further: "However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. Study: Millions Treated for Hypothyroidism At R - Thyroid UK undefined will no longer be visible to you including posts, replies, and photos. It was the therapist that I went to that referred me to a specialist who ran the correct tests. I think there is always a lot of confusion with cause and cure. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. Salt, Sugar, Fat: 15 Shocking Facts From the Book Dear Doctor, Do You Really Know What Vaccines Cont Colloidal Gold: Discover the Benefits and Wonders, Scientists Explain Why HPV Vaccines Are Unsafe. In 2020 alone, there were more than 2.2 million new cases and 1.8 million deaths from lung cancer globally. The American Lung Association connects patients, families, friends and caregivers for support and inspiration as they face lung cancer. [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore back up causing excessive T4 activity, i.e. Ultimately, this latest Italian study is bringing to our attention one of what is likely a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. View the data on GreenMedInfos Hypothyroidism Research page. Overtreatment, of course, is the hallmark danger of overdiagnosis. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. They found no significant correlation between T4 sales and breast, colorectal and gastric cancers, but did find a significant correlation for lung cancer (p < 0.05) corrected for smoking and age. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. It looks at correlations, as if they had any merit on their own. millions treated for hypothyroidism at risk for lung cancer Are you sure you want to block this member? END TIME NEWS, A CALL FOR REPENTANCE, YESHUA THE ONLY WAY TO HEAVEN. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5'-monodeiodination (DI). [7] Kinoshita S, Sone S, Yamashita T, Tsubura E, Ogura T: Effects of experimental hyperand hypothyroidism on natural defense activities against Lewis lung carcinoma and its spontaneous pulmonary metastases in C57BL/6 mice. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective c [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. Most of the time, doctors tell patients treated with LT4 that any side effects will be temporary and almost ineluctable, and are usually dealt with through dose reduction. [8] van Doorn J, Roelfsema F, van der Heide D: Concentration of thyroxine and 3,5,3'-triiodotyronine in several rat tissue in vivo: the effect of hypothyroidism. JavaScript is disabled. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. Not what people like me are saying. ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. Compression of the trachea, which may be positional, can occur with nodular goiters and thyroid cancer, and the latter can metastasize to the lungs. ", That study is like a fishing expedition. hyperthyroidism. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. is the fiec part of the evangelical alliance; townhomes in avalon park; 8 ft windmill parts; why is my cash and sweep vehicle negative; nordstrom rack return policy worn shoes elevated TSH, without actually improving the overall physiological situation, nor the patient's subjective experience of well being. Note: Only a member of this blog may post a comment. Hashimoto's disease - Symptoms and causes - Mayo Clinic The increasingly global medical-industrial complex has begun to co-opt all aspects of the natural human bodily life cycle, and all the organ systems within it, as potential targets of medical surveillance and intervention, not excluding the human thyroid. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. Metab.87 (2): 48999. Baked or Fried avocado fries [Vegetarian]. Patients with undertreated hypothyroidism at higher risk for longer 2002 Feb ;25(2):106-9. Angiology 2000, 51:S65S68. I have no further scientific evidence. This website is for information purposes only. Currently, the best practical approach is to base treatment decisions on the degree of TSH elevation, thyroid autoimmunity, and associated comorbidities. View the data on our Hypothyroidism Research page. A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Hypothyroidism: symptoms, causes, treatment, medicine, prevention Share your experience, learn from others. ", Cure Alveolar Soft Part Sarcoma International, COMPLETED - Dana Farber Vaccine Clinical Trial (GVAX), Axitinib and Pembrolizumab (Keytruda) in Miami, US, TECENTRIQ (atezolizumab) by Genentech, Treatment of Non-Resectable Primary Tumor, Immune checkpoint inhibitors ICI (PD-1 and PD-L1 targeting drugs), Toxicity, problems and potentiation strategies, Treatment response criteria and evaluation/scanning problems/rare cases, treatment discontinuation/re-treatment, Side effects/complications of the local ablations, High intensity focused ultrasound (HIFU), Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, http://www.greenmedinfo.com/blog/study- ng-cancers. Non-small cell lung cancer is the most common type of lung cancer, accounting for about 81% of all cases. They also noted that oxidative stress is one of the causes of chronic diseases and cancer. hyperthyroidism. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? 1 The number of individuals with thyroid disorders is expected to continue to grow, having reached approximately 750 million globally in 2012. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? BUT, this is the first I have heard of the potential risk of lung cancer in those who take Synthyroid. LOL. Targeted therapy for lung cancer: Side effects and more [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. [14] K A Woeber. I don't think so. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. Monaldi Arch Chest Dis 2003, 59:140145. millions treated for hypothyroidism at risk for lung cancer. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. If it's high, the test is done again, along with a blood test for the thyroid hormone T-4. Millions Treated for Hypothyroidism at Risk for Lung Cancer LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Grass Fed Organs & Glandulars - Nano Soma. Scan this QR code to download the app now. Furthermore, the geometric expansion of hypothyroidism cases in the past decade only thinly conceals an agenda to promote the synthetic form of T4 known as levothyroxine sodium (trade name Synthroid), since with each new 'disease' case the patient is converted into a lifelong customer. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. Whether it should be treated remains controversial. Perhaps she and I could co-author? In my view the paper isn't worth the pixels used to display it on a screen. http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-l Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, Iodine Supplementation Support by VWT Team. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. [15] [16]There is also the more logical option of support the bodys thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. weight loss, anorexia). " [13] Hollowell JG, Staehling NW, Flanders WD, et al. Thank you for bringing it to our attention. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. Millions of people who were not only wrongly diagnosed with 'cancers' and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. Yes, lung cancer patients can have these symptoms, but so do patients who have other cancers. PMID: 23539727, [16] Alan R Gaby. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. All the more reason to prescribe T3, I say! Increased sleepiness. A distorted idea of human nature is sold when people are treated as "the market. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. You may not notice signs or symptoms of the disease. Study: Millions Treated for - Healing Lyme Disease | Facebook One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. Symptoms. J. Clin. I invite those interested to read it and perhaps we can have a discussion on this study. UpToDate Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. Clin Cancer Res 2011, 30:77. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. Thyroid dysfunction after immune checkpoint inhibitor treatment in a single-center Chinese cohort: a retrospective study Symptoms can include fatigue, shortness of breath with exercise, and decreased ability to exercise. [5] Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5' deiodinase in lung cancer with peripheral lung tissues. Hashimoto's disease progresses slowly over the years. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' Or, simply look at what the young-adult, T-score based definition of osteoporosis and osteopenia has done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. Savvy Senior: Could you have a thyroid problem and not even know it? Why not simply call it selenium deficiency? I am just as much in the dark as some others on this site. However, they pointed out that the opposite was actually described, and that hypothyroidism reduces the aggressiveness of some cancers because of the presence of thyroid hormone receptors on cancer cells, and spontaneous hypothyroidism may delay onset or reduce aggressiveness of cancers.[1]. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. 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Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: Recently T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. [3], An old clinical observation on the relationship between lung cancer and thyroid function reported that patients were characterized by a low concentration of T3 and an increased T4/T3 ratio due to a decrease of 5-monodeiodination (DI). The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. If you are already a member, please, Levothyroxine and lung cancer in females: the importance of oxidative stress, recent announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? The first blood test typically done to diagnose hypothyroidism measures the level of thyroid-stimulating hormone (TSH) in the blood. Is Drug-Based Medicine a Form of Human Sacrifice? Angiology 2000, 51:S65S68. 16.6k members in the AlternativeHealth community. The great open sky of imagination: for those who u Fermented Foods: Top 8 Reasons to Eat Them. She wrote about a product called Thyrtophin PMG. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Military veterans face increased risk of HPV-related cancer due to low Now, I will bring it to the attention of my Endocrinologist. It is worth reading. [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. El almacenamiento o acceso tcnico que se utiliza exclusivamente con fines estadsticos annimos. It's usually based on the results of blood tests. Find how some diseases can be healed with alternative medicine, and share your experience with See more of Keri Topouzian, D.O. The authors delved deeper into the reason why oxidative stress taking place during T4 treatment is particularly linked to lung cancer only: The hypothesis could be that in lungs the increase of hypoxia-induced factor (HIF-1) which is determined by T4 can make oxygen much more available, increasing locally the oxidative stress together with a dangerous angiogenesis stimulation. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' elevated TSH, without actually improving the overall physiological situation, nor the patients subjective experience of well being. In comparison, 62.4% of female and 37% of male . However, that information will still be included in details such as numbers of replies. Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. 1). I am having a lot of trouble making any sense of this study. The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Asesora y Consultora Web3 para empresas. I have so much to say about this I could write a book. They compared sale of, "However, the impression we get from our experience, Health, Studies, Supps & Pharmaceuticals. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). J Endocrinol Invest. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. video where the doc is talking about the study , i wlll link study and video below. Link posted. and our In addition, untreated hypothyroidism is associated with a gradual decline in cognitive function and memory. Dr Childs guesses that patients on levothyroxine monotherapy may be more prone to cancer because they might be under-treated. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. Cookie Notice I wish I could say that my story was atypical. Cancer Risk After Radioactive Iodine Treatment for - PubMed 2 Hypothyroidism is the most common type of thyroid disorder, and women's risk of hypothyroidism is five to eight times higher than that of . millions treated for hypothyroidism at risk for lung cancer

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